Diabetes
Paragraphs

David Studdert and colleagues explore how to balance public health, individual freedom, and good government when it comes to sugar-sweetened drinks. Over the last decade, many national, state, and local governments have introduced laws aimed at curbing consumption of sugar-sweetened beverages (SSBs), especially by children. The main regulatory approaches are taxes, restrictions on the availability of SSBs in schools, restrictions on advertising and marketing, labeling requirements, and government procurement and benefits standards. Efforts to regulate in this area often encounter stiff opposition, including claims that the laws are inequitable, do not achieve their goals, and have negative economic effects. Several lessons can be drawn from the international experience with SSB regulation to date, which may inform future design and implementation of legal interventions to combat noncommunicable disease.

All Publications button
1
Publication Type
Journal Articles
Publication Date
Journal Publisher
PLOs
Authors
David Studdert
David Studdert
Michelle Mello
Michelle M. Mello
Jordan Flanders
Number
7
News Type
News
Date
Paragraphs

A rapidly aging population poses serious challenges for many countries around the world, particularly in Asia, home to the most populous countries. China and India account for nearly 36% of the world’s population, and are expected to face social and economic complications from demographic change in the next decades.

A special issue of the Journal of the Economics of Ageing explores these trends in a comparative perspective, “The Economic Implications of Population Ageing in China and India” (December 2014), co-edited by David Bloom, a professor at Harvard University’s School of Public Health, and Karen Eggleston, a Center Fellow at the Shorenstein Asia-Pacific Research Center.

“Population ageing represents uncharted waters for China and India,” Bloom and Eggleston write in their coauthored introduction.

The special issue is a collection of 10 articles that examine the economic benefits and potential dilemmas arising from decreased fertility and increased life expectancy, two trends that will impact the development and future trajectories of China and India at the micro- and macroeconomic levels.

Dropping or continued low birth rates imply fewer young people to refresh the labor market. But will this cause the workforce to shrink to an unsustainable level? Demand will increase for health care, long term care, and other social services that support the elderly. What must the government do to ensure adequate access to care?

Empirical data and commentary presented in the special issue seek to inform stakeholders about emerging patterns, and to provide insight on how to best address related policy challenges going forward.

“By adopting responsive behaviors and consultative institutions that address the challenges of population ageing in ways that are appropriate to their unique circumstances, China and India could reap the full economic and social benefits of longer, healthier lives,” they write.

The special issue includes an introduction by Bloom and Eggleston, a feature interview with Richard Suzman, and additional analysis by noted global health experts following each article. The titles and authors of the 10 original research articles are listed below:

  • Intergenerational co-residence and schooling (Anjini Kochar)
  • Regional disparities in adult height, educational attainment, and late-life cognition: Findings from the Longitudinal Aging Study in India (LASI) (Jinkook Lee, James P. Smith)
  • Healthy aging in China (James P. Smith, John Strauss, Yaohui Zhao)
  • Gender differences in cognition in China and reasons for change over time: Evidence from CHARLS (Xiaoyan Lei, James P. Smith, Xiaoting Sun, Yaohui Zhao)
  • Reprint of: Health outcomes and socio-economic status among the mid-aged and elderly in China: Evidence from the CHARLS national baseline data (Xiaoyan Lei, Xiaoting Sun, John Strauss, Yaohui Zhao, Gonghuan Yang, Perry Hu, Yisong Hu, Xiangjun Yin)
  • Should China introduce a social pension? (Bei Lu, Wenjiong He, John Piggott)
  • China’s age of abundance: When might it run out? (Yong Cai, Feng Wang, Ding Li, Xiwei Wu, Ke Shen)
  • The macroeconomic impact of non-communicable diseases in China and India: Estimates, projections, and comparisons (David E. Bloom, Elizabeth T. Cafiero-Fonseca, Mark E. McGovern, Klaus Prettner, Anderson Stanciole, Jonathan Weiss, Samuel Bakkila, Larry Rosenberg)
  • Economic development and gender inequality in cognition: A comparison of China and India, and of SAGE and the HRS sister studies (David Weir, Margaret Lay, Kenneth Langa)
  • Comparing the relationship between stature and later life health in six low and middle income countries (Mark E. McGovern)

The special issue of the Journal of the Economics of Ageing, vol. 4, pages 1-154 (December 2014) is available through Elsevier’s online platform ScienceDirect.

All News button
1
Shorenstein APARC616 Serra StreetEncina Hall E301Stanford, CA 94305-6055
(650) 725-2507 (650) 723-6530
0
pham_ngoc_minh.jpg
Ph.D.

Pham Ngoc Minh joins the Walter H. Shorenstein Asia-Pacific Research Center (Shorenstein APARC) as the 2014-2015 Developing Asia Health Policy Fellow as a health researcher and administrator.

His main interests are public health, disease prevention and the rural-urban divide in developing countries. At Stanford, Pham will be studying epidemiological trends and policy perspectives of diabetes in Vietnam, particularly those among adults in mountainous areas of that country. Pham has more than six years of experience working as a medical lecturer at the Thai Nguyen University of Medicine and Pharmacy in Vietnam, and spent two and a half years conducting postdoctoral research in Japan. He received a Bachelor of Medicine from the Thai Nguyen University of Medicine and Pharmacy, a BA in English from Hanoi University, an MPH from the University of Melbourne, and a PhD in medical science from Kyushu University.

2014-2015 Developing Asia Health Policy Postdoctoral Fellow
-

This symposium will highlight the public health threat posed by China’s non-­‐ communicable disease (NCD) epidemic, and focus on the role of research in developing an effective response. Prevalent NCDs (stroke, diabetes, heart disease, and cancer) share common origins linked to lifestyle changes and increasing disease risk factors spurred in part by successful economic development. These conditions and their complications, however, place a high burden on health care resources and reduce social capital growth. An effective response is possible, but will require a novel approach focusing on maintaining human function and wellness, strategies that impact multiple NCDs, new models of health care delivery, and greater integration of public health and clinical care.

Featured speakers include Prof. Linhong WANG (China Center for Disease Control), Prof. Lixin JIANG (National Centre for Cardiovascular Diseases), Prof. Yangfeng WU (Peking University Clinical Research Institute) Prof. Randall S. STAFFORD (Stanford Prevention Research Center), Prof. Sanjay BASU (Stanford Prevention Research Center).

Stanford Center at Peking University

Randall S. STAFFORD Professor Moderator Stanford Prevention Research Center
Seminars
Paragraphs
Abstract

Background: Body mass index (BMI) and waist circumference (WC) are used in risk assessment for the development of noncommunicable diseases (NCDs) worldwide. Within a Cambodian population, this study aimed to identify an appropriate BMI and WC cutoff to capture those individuals that are overweight and have an elevated risk of vascular disease.

Methodology/Principal Findings: We used nationally representative cross-sectional data from the STEP survey conducted by the Department of Preventive Medicine, Ministry of Health, Cambodia in 2010. In total, 5,015 subjects between age 25 and 64 years were included in the analyses. Chi-square, Fisher’s Exact test and Student t-test, and multiple logistic regression were performed. Of total, 35.6% (n=1,786) were men, and 64.4% (n=3,229) were women. Mean age was 43.0 years (SD = 11.2 years) and 43.6 years (SD = 10.9 years) for men and women, respectively. Significant association of subjects with hypertension and hypercholesterolemia was found in those with BMI $23.0 kg/m2 and with WC .80.0 cm in both sexes. The Area Under the Curve (AUC) from Receiver Operating Characteristic curves was significantly greater in both sexes (all p-values, 0.001) when BMI of 23.0 kg/m2 was used as the cutoff point for overweight compared to that using WHO BMI classification for overweight (BMI $25.0 kg/m2) for detecting the three cardiovascular risk factors. Similarly, AUC was also significantly higher in men (p-value, 0.001) when using WC of 80.0 cm as the cutoff point for central obesity compared to that recommended by WHO (WC $94.0 cm in men).

Conclusion: Lower cutoffs for BMI and WC should be used to identify of risks of hypertension, diabetes, and hypercholesterolemia for Cambodian aged between 25 and 64 years.

All Publications button
1
Publication Type
Journal Articles
Journal Publisher
PLoS ONE
Authors
Yom An
Siyan Yi
Annette Fitzpatrick
Vinay Gupta
Piseth Raingsey Prak
Sophal Oum
James P. LoGerfo

Advanced Registration for this conference is required.  For more information and to register, please click here.

 

Overview

 This conference focuses on economic aspects of diabetes and its complications.

 

 A major focal point of the conference will be a comparison of health economic diabetes models both in terms of their structure and performance. This conference builds on six previous diabetes simulation modelling conferences that have been held since 1999. A write-up of a past conference can found by here.

 

A particular theme of the 2014 challenge will be how to generalise diabetes simulation models for different populations and over time. To what degree are existing models able to adjust for differences risk due to ethnic and socio-economic differences as well as any secular improvements in diabetes care?"

The conference will also have open sessions on all aspects of the health economics of diabetes.

Following previous Mount Hood Challenges, the emphasis will be on comparing model projections to real world or clinical trial outcomes, and explanation and discussion of differences seen between each model and the real world results.

 

Abstract submissions are invited on the following themes

(1) Modelling diabetes disease progression and its complications

(2) Effect of diabetes on society – its impact on life and work

(3) Economic approaches to measuring quality of life

(4) Quantifying the cost of diabetes and its complications

(5) Methodological aspects of diabetes modelling

 

Abstract Submission Requirements

 

ALL ABSTRACTS ARE TO BE SUBMITTED via email mthood2014@gmail.com

 

SUBMISSION DEADLINE: Friday 28th March 2014

 

ALL ABSTRACT SUBMISSIONS AND PRESENTATIONS MUST BE IN ENGLISH.

Conference registration is required for all presenters. Note if the abstract is not accepted for presentation, participants that have registered can withdraw from the conference prior to end of April 2014 without financial penalty.

 

The presenters of research are required to disclose financial support. Abstract review will NOT be based on this information.

 

The research abstracts, EXCLUDING title and author information, should be no longer than 300 words.

 

The use of tables, graphs and figures in your research abstract submission are not allowed.

 

Generic names should be used for technologies (drugs, devices), not trade names.

 

Research that has been published at any national or international meeting prior to this Conference is discouraged.

 

MULTIPLE ABSTRACTS ON THE SAME STUDY ARE DISCOURAGED.

Abstracts will be reviewed by the steering committee and notification of acceptance or rejection will be made by 15th April 2014

 

Bechtel Conference Center

Conferences
Paragraphs

Abstract:

OBJECTIVE Human blood glucose levels have likely evolved toward their current point of stability over hundreds of thousands of years. The robust population stability of this trait is called canalization. It has been represented by a hyperbolic function of two variables: insulin sensitivity and insulin response. Environmental changes due to global migration may have pushed some human subpopulations to different points of stability. We hypothesized that there may be ethnic differences in the optimal states in the relationship between insulin sensitivity and insulin response.

RESEARCH DESIGN AND METHODS We identified studies that measured the insulin sensitivity index (SI) and acute insulin response to glucose (AIRg) in three major ethnic groups: Africans, Caucasians, and East Asians. We identified 74 study cohorts comprising 3,813 individuals (19 African cohorts, 31 Caucasian, and 24 East Asian). We calculated the hyperbolic relationship using the mean values of SI and AIRg in the healthy cohorts with normal glucose tolerance.

RESULTS We found that Caucasian subpopulations were located around the middle point of the hyperbola, while African and East Asian subpopulations are located around unstable extreme points, where a small change in one variable is associated with a large nonlinear change in the other variable.

CONCLUSIONS Our findings suggest that the genetic background of Africans and East Asians makes them more and differentially susceptible to diabetes than Caucasians. This ethnic stratification could be implicated in the different natural courses of diabetes onset.

Canalization is the way in which organisms develop phenotypic robustness as a response to genetic or environmental perturbations. This process ensures the stability of critical biological processes like blood glucose regulation. Canalization of this trait can be represented by a hyperbolic function of two underlying variables: insulin sensitivity and insulin response, as primarily described by Kahn et al. (1,2).

Global migration in the early history of Homo sapiens placed people in new environments, resulting in novel diets, food scarcity, different climates, and exposure to novel pathogens. These changes may have shifted population averages of factors that influence insulin sensitivity and secretion. They include body size, body composition, energy expenditure, storage, and heat production. As these factors changed, they may have disclosed cryptic genetic variation or adopted novel mutations, leading to disruption of the unique point of stable equilibrium of ancestral populations. As this process continued over hundreds of millennia, specific genetic and environmental perturbations may have pushed some subpopulations to different points of stability (1,35).

We hypothesized that there may be ethnic differences in the optimal states in the relationship between insulin sensitivity and insulin response and that these differences may depend on a population’s genetic or evolutionary history. To assess this hypothesis, we performed a systematic review and a meta-analysis of studies of the insulin sensitivity index (SI) and the acute insulin response to glucose (AIRg). Our analysis was done in cohorts in any of the three major ethnic groups: Africans, Caucasians, and East Asians. We found significant differences between the groups.

All Publications button
1
Publication Type
Journal Articles
Publication Date
Journal Publisher
Diabetes Care
Authors
Keiichi Kodoma
Damon Tojjar
Satoru Yamada
Kyoko Toda
Chirag J. Patel
Atul J.Butte
Authors
Ashley Dean
News Type
News
Date
Paragraphs

Outside of China, the world now has more food insecure and nutrient deficient people than it had a decade ago, and the prevalence of obesity-related diabetes, high blood pressure and cardio-vascular diseases is increasing at very rapid rates. Expanded food production has done little to address the fact that between one-third and one-half of all deaths in children under five in developing countries are still related to malnutrition.

“With only three years away from the Millennium Development Goals deadline, this is a terrible track record,” said food and nutrition policy expert Per Pinstrup-Andersen at FSE's Global Food Policy and Food Security Symposium Series last week.  

Pinstrup-Andersen, the only economist to win the World Food Prize (the ultimate award in the food security field), has dedicated his career to understanding the linkages between food, nutrition, and agriculture. What is driving persistent food insecurity and malnutrition in a food abundant world?

Poor food supply management is part of the problem. According to the United Nations Food and Agricultural Organization (FAO), 20-30% of food produced globally is lost every year. That’s enough to feed an additional 3-3.5 billion people.

Jatropha in Africa. Photo credit: Ton Rulkens/flickr.

Biofuels production, such as jatropha in Africa, now competes with food for land, and climate change is already negatively impacting crop yields in regions straddling the equator—with major implications for food supply.

For low-income consumers in both the U.S. and developing countries increasing and more volatile food prices, such as those seen in 2007, are also driving food insecurity. Poor consumers respond by purchasing cheaper, less nutrient food, and less of it.

Nutritional value chain

Consensus is developing—at least rhetorically—among national policymakers and international organizations that investments in agricultural development must be accelerated. Members of the G8 and G20 have committed $20 billion in international economic support for such investments and some developing countries such as Ethiopia and Ghana are planning large new investments.

While most of these recent initiatives focus on expanded food supplies, there is an increasing understanding that merely making more food available will not assure better food security, nutrition, and health at the household and individual levels.

“It matters for health and nutrition how increasing food supplies are brought about and of what it consists,” said Pinstrup-Andersen. “We need to turn the food supply chain into a nutritional value chain.”

Diet diversity is incredibly important for good nutrition. Agricultural researchers and food production companies need to look at a number of different commodities, not just the major food staples, said Pinstrup-Andersen.

“The Green Revolution successfully increased the production of corn, rice, and wheat, increasing incomes for farmers, and lowering prices for consumers, but now it is time to invest in fruits, vegetables and biofortification to deal with micronutrient deficiency,” said Pintrup-Andersen.

Biofortification, the breeding of crops to increase their nutritional value, offers tremendous opportunity for dealing with malnutrition in the developing world, but is not widely available.

This is particularly important for areas in sub-Saharan Africa where between one and three and one and four people are short in calories, protein, and micronutrients. Obesity is actually going up in these countries with the introduction of cheap, processed, energy-dense foods (those high in sugar and fat) contributing to the diabetes epidemic.

Pathways to better health

Women hauling water to their gardens in Benin.

The path to better health and nutrition must look beyond the availability of food at affordable prices, clean water, and good sanitation, and consider behavioral factors such as time constraints for women in low-income households.

“Field studies have shown time and time again that one of the main factors preventing women from providing themselves and their families with good nutrition is time,” explained Pinstrup-Andersen.

He told the story of a woman in Bolivia too burdened with farm and household responsibilities to take the time to breastfeed her six-month old daughter. Enhancing productivity in activities traditionally undertaken by women could be a key intervention to improving good health and nutrition at the household level.

Access is another issue. A household may be considered food secure, in that sufficient food may be available, but food may not be equally allocated in the household.

“If we focus on the most limiting constraint we can be successful,” said Pinstrup-Anderen. “But we must tailor our response to each case.”

For sub-Saharan Africa, this includes investments in rural infrastructure, roads, irrigation systems, micronutrient fertilizer, climate adaptation strategies, and other barriers holding back small farmers.

Fortunately, there has been a renewed attention to the importance of guiding food system activities towards improved health and nutrition. The Global Agriculture and Food Security Program (GAFSP), which facilitates the distribution of some of the G8 and G20 $20 billion commitments, prescribes that country proposals for funding of agricultural development projects must show a clear pathway from the proposed agricultural change to human nutrition.

“But it’s not going to be easy to implement good policies,” warned Pinstrup-Andersen. “There are few incentives in government for multidisciplinary problem solving. The economy is set up around silos and people are loyal to their silos. Agricultural and health sectors are largely disconnected in their priorities, policy, and analysis."

Incentives must change to encourage working across ministries and disciplines to identify the most important health and nutrition-related drivers of food systems, impact pathways, and policy and program interventions to find win-wins for positive health and nutrition.

All News button
1
Authors
Erin Digitale
News Type
Q&As
Date
Paragraphs

Instilling healthy eating and exercise habits in children may help prevent obesity later in life. But which kids most need such obesity-prevention efforts? A recent study by Jeremy Goldhaber-Fiebert and colleagues at Stanford's School of Medicine showed that this question is harder to answer than it seems. The study, published earlier this year in Medical Decision Making, found that targeting obesity prevention to small children who are overweight might not be effective. That's because a higher-than-normal weight at age 5 provides an accurate predictor of adult obesity only 50 percent of the time.

Goldhaber-Fiebert, an assistant professor of medicine and core faculty member of Stanford Health Policy, discusses the problem.

What does your paper tell us about the recent focus on childhood and adolescent obesity measurements?

Our study has two take-home messages. First, while childhood obesity is an important problem, solving childhood obesity alone will not solve future adult obesity problems. Second, addressing future adult obesity will require broader societal measures — not simply interventions focused on obese children.

It used to be that no one worried much if a small child was chubby; the doctor might say, "It's baby fat, he'll grow out of it." How has that changed?

In fact, our data show that many children still do "grow out of it." But our findings suggest that it is difficult to predict whether this will happen for a specific child. Consequently, efforts to help obese children must be connected to broader efforts to create healthy diets and habits for all children.

Childhood obesity is concerning both because it presents increased health risks for individuals while they are children and also because of the fear that it will translate into serious adult obesity-related health issues. Our analyses show that targeting children who are already obese is unlikely to be sufficient in addressing broader public health challenges of obesity in later childhood, adolescence and adulthood.

Are there other more promising screening criteria for chronic adult obesity instead of using a child's weight?

It really depends on the purpose of screening. Researchers have identified a variety of characteristics to predict a child's future obesity status — for example, easily observed measures like the weight of a child's parent as well as more complex measures such as their size at birth and the rapidity with which they subsequently grew and gained weight.

The challenge is to have a measure that both does not miss a substantial fraction of those who become obese later on and also does not falsely predict obesity for a large number of those who do not become obese as adults. The trade-off between these two types of errors depends on the seriousness of health implications of obesity and the costs of treating health conditions once they arise, as well as the health and economic costs of delivering preventive interventions to people who are identified as being at risk of becoming obese regardless of whether they become obese in the future.

What are some of the best potential approaches for reducing childhood obesity if the entire population is being targeted?

Given that many health-related habits are developed in childhood, efforts to create healthy eating and exercise habits in children would seem to be beneficial. But for most potential interventions, we lack evidence of their widespread effectiveness over a long period of time. Do reductions in obesity persist from childhood into adulthood? Do they lead to measurable improvements in health outcomes? We do not have answers to these key questions.

Food, beverage or sugar taxes and other manipulations to food prices or availability may be effective, but may also have unintended harms and certainly come at the cost of curtailing personal choice. Re-engineering the built environment or nudging people with various behavioral/economic mechanisms have garnered attention though, again, widely generalizable evidence on them is lacking. The problem deserves continued creativity and ongoing evaluation and testing.

Your paper focuses on which obese children will become obese adults, yet we are seeing a growing number of children experiencing type-2 diabetes and other negative health consequences of being overweight before they're even out of their teen years. Is adult obesity the best endpoint to focus on?

Obesity-related conditions of childhood clearly should not be ignored. What we are concerned about is the sense that people were conflating good care for children to deal with their shorter-term health needs (i.e., childhood obesity management to deal with childhood health issues) and the belief that such an approach might largely solve the broader adult obesity issues. Addressing childhood obesity is still important even if it does not fix adult obesity and its deleterious health consequences.

Erin Digitale is the pediatrics writer for Stanford School of Medicine's Office of Communication and Public Affairs.

All News button
1
Paragraphs

OBJECTIVE To assess the individual financial impact of having diabetes in developing countries, whether diabetic individuals possess appropriate medications, and the extent to which health insurance may protect diabetic individuals by increasing medication possession or decreasing the risk of catastrophic spending.

RESEARCH DESIGN AND METHODS Using 2002–2003 World Health Survey data (n = 121,051 individuals; 35 low- and middle-income countries), we examined possession of medications to treat diabetes and estimated the relationship between out-of-pocket medical spending (2005 international dollars), catastrophic medical spending, and diabetes. We assessed whether health insurance modified these relationships.

RESULTS Diabetic individuals experience differentially higher out-of-pocket medical spending, particularly among individuals with high levels of spending (excess spending of $157 per year [95% CI 130–184] at the 95th percentile), and a greater chance of incurring catastrophic medical spending (17.8 vs. 13.9%; difference 3.9% [95% CI 0.2–7.7]) compared with otherwise similar individuals without diabetes. Diabetic individuals with insurance do not have significantly lower risks of catastrophic medical spending (18.6 vs. 17.7%; difference not significant), nor were they significantly more likely to possess diabetes medications (22.8 vs. 20.6%; difference not significant) than those who were otherwise similar but without insurance. These effects were more pronounced and significant in lower-income countries.

CONCLUSIONS In low-income countries, despite insurance, diabetic individuals are more likely to experience catastrophic medical spending and often do not possess appropriate medications to treat diabetes. Research into why policies in these countries may not adequately protect people from catastrophic spending or enhance possession of critical medications is urgently needed.

All Publications button
1
Publication Type
Journal Articles
Publication Date
Journal Publisher
Diabetes Care
Authors
Crystal Smith-Spangler
Jay Bhattacharya
Jay Bhattacharya
Jeremy Goldhaber-Fiebert
Jeremy Goldhaber-Fiebert
Subscribe to Diabetes